| Player | Runs | Balls | 4s | 6s | SR | Opposition | Ground | Match Date |
|---|---|---|---|---|---|---|---|---|
| Ahmed Shehzad | 111 | 62 | 10 | 5 | 179.03 | Bangladesh | Dhaka | 30 Mar 2014 |
| Ahmed Shehzad | 98 | 64 | 6 | 6 | 153.13 | Zimbabwe | Harare | 24 Aug 2013 |
| Babar Azam | 97 | 58 | 13 | 1 | 167.24 | West Indies | Karachi | 02 Apr 2018 |
| Umar Akmal | 94 | 54 | 9 | 4 | 174.07 | Australia | Dhaka | 23 Mar 2014 |
| Fakhar Zaman | 91 | 46 | 12 | 3 | 197.83 | Australia | Harare | 08 Jul 2018 |
| Babar Azam | 90 | 58 | 13 | 1 | 155.17 | South Africa | 03 Feb 2019 | |
| Sarfraz Ahmed | 89 | 49 | 10 | 3 | 181.63 | Scotland | 12 Jun 2018 | |
| Ahmed Shehzad | 89 | 55 | 8 | 3 | 161.82 | World-XI | Lahore | 15 Sep 2017 |
| Misbah-ul-Haq | 87 | 53 | 3 | 5 | 164.15 | Bangladesh | Karachi | 20 Apr 2008 |
| Babar Azam | 86 | 52 | 10 | 2 | 165.38 | World-XI | Lahore | 12 Sep 2017 |
| Mohammad Hafeez | 86 | 51 | 9 | 4 | 168.63 | South Africa | Centurion | 03 Mar 2013 |
| Mukhtar Ahmed | 83 | 45 | 12 | 3 | 184.44 | Zimbabwe | Lahore | 22 May 2015 |
| Babar Azam | 79 | 58 | 7 | 2 | 136.21 | New Zealand | Dubai International Cricket Stadium | 04 Nov 2018 |
| Sarfraz Ahmed | 76 | 64 | 8 | 2 | 118.75 | New Zealand | Dubai (DSC) | 04 Dec 2014 |
| Shoaib Malik | 75 | 54 | 8 | 2 | 138.89 | England | Sharjah | 30 Nov 2015 |
| Salman Butt | 74 | 56 | 6 | 3 | 132.14 | Canada | King City (NW) | 10 Oct 2008 |
| Fakhar Zaman | 73 | 42 | 9 | 3 | 173.81 | Australia | Sialkot | 05 Jul 2018 |
| Salman Butt | 73 | 46 | 8 | 2 | 158.70 | Bangladesh | Gros Islet | 01 May 2010 |
| Kamran Akmal | 73 | 55 | 8 | 1 | 132.73 | Bangladesh | Gros Islet | 01 May 2010 |
| Imran Nazir | 72 | 36 | 9 | 3 | 200.00 | Bangladesh | Pallekele | 25 Sep 2012 |
| Mohammad Hafeez | 71 | 48 | 6 | 3 | 147.92 | Zimbabwe | Harare | 16 Sep 2011 |
| Ahmed Shehzad | 70 | 50 | 6 | 1 | 140.00 | Zimbabwe | Harare | 23 Aug 2013 |
| Babar Azam | 68 | 55 | 5 | 1 | 123.64 | Australia | Abu Dhabi | 24 Oct 2018 |
| Salman Butt | 67 | 54 | 8 | 1 | 124.07 | New Zealand | Bridgetown | 08 May 2010 |
| Misbah-ul-Haq | 66 | 42 | 7 | 1 | 157.14 | Australia | Johannesburg | 18 Sep 2007 |
| Babar Azam | 65 | 42 | 5 | 3 | 154.76 | England | 05 May 2019 | |
| Mohammad Hafeez | 64 | 42 | 7 | 2 | 152.38 | Bangladesh | Kolkata | 16 Mar 2016 |
| Umar Akmal | 64 | 37 | 5 | 4 | 172.97 | South Africa | Cape Town | 22 Nov 2013 |
| Umar Akmal | 64 | 31 | 7 | 3 | 206.45 | Australia | Birmingham | 05 Jul 2010 |
| Kamran Akmal | 64 | 33 | 7 | 2 | 193.94 | Australia | Melbourne | 05 Feb 2010 |
| Hussain Talat | 63 | 41 | 8 | 1 | 153.66 | West Indies | Karachi | 02 Apr 2018 |
| Shoaib Malik | 63 | 49 | 7 | 3 | 128.57 | UAE | Dhaka | 29 Feb 2016 |
| Mohammad Hafeez | 63 | 41 | 5 | 3 | 153.66 | South Africa | Cape Town | 22 Nov 2013 |
| Mukhtar Ahmed | 62 | 40 | 6 | 1 | 155.00 | Zimbabwe | Lahore | 24 May 2015 |
| Mohammad Hafeez | 61 | 47 | 8 | 2 | 129.79 | New Zealand | Auckland | 15 Jan 2016 |
| Mohammad Hafeez | 61 | 44 | 6 | 2 | 138.64 | India | Bengaluru | 25 Dec 2012 |
| Khalid Latif | 59 | 42 | 8 | 2 | 140.48 | England | Manchester | 07 Sep 2016 |
| Sharjeel Khan | 59 | 36 | 7 | 3 | 163.89 | England | Manchester | 07 Sep 2016 |
| Kamran Akmal | 59 | 42 | 5 | 3 | 140.48 | Australia | Dubai (DSC) | 07 May 2009 |
| Imran Nazir | 59 | 41 | 3 | 5 | 143.90 | New Zealand | Cape Town | 22 Sep 2007 |
| Sarfraz Ahmed | 58 | 42 | 5 | 2 | 138.10 | Bangladesh | Dhaka | 02 Mar 2016 |
| Imran Nazir | 58 | 38 | 5 | 4 | 152.63 | New Zealand | Dubai (DSC) | 12 Nov 2009 |
| Shoaib Malik | 57 | 50 | 3 | 3 | 114.00 | India | Bengaluru | 25 Dec 2012 |
| Kamran Akmal | 57 | 51 | 5 | 1 | 111.76 | Ireland | The Oval | 15 Jun 2009 |
| Shoaib Malik | 57 | 31 | 4 | 2 | 183.87 | Sri Lanka | Johannesburg | 17 Sep 2007 |
| Umar Akmal | 56 | 27 | 4 | 4 | 207.41 | New Zealand | Hamilton | 17 Jan 2016 |
| Nasir Jamshed | 56 | 35 | 2 | 4 | 160.00 | New Zealand | Pallekele | 23 Sep 2012 |
| Umar Akmal | 56 | 35 | 2 | 4 | 160.00 | Australia | Gros Islet | 14 May 2010 |
| Umar Akmal | 56 | 49 | 5 | 1 | 114.29 | New Zealand | Dubai (DSC) | 13 Nov 2009 |
| Hussain Talat | 55 | 41 | 7 | 1 | 134.15 | South Africa | 03 Feb 2019 |
